Just like people, dogs can get lupus. Its an autoimmune disease, meaning that the immune system mistakes the bodys own tissues for foreign invaders and starts attacking and destroying them. Two types of lupus strike our canine pets: systematic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). The first is much more devastating, with worse symptoms that can have life-threatening implications. The second is not as dangerous but needs to be brought under control to avoid serious complications down the line.